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Dominate her and tied fingered Helpless teenager Evelyn has been walking for awhile. Researchers have already used the new imaging technique to confirm that receptor levels are depleted in drug users and obese patients.

It's not yet clear whether the low receptor levels are a consequence of behavior, genetics, or both. Second, details about the orgasm cycle could potentially make it easier to sustain monogamous contentment. Even though we pair-bonding humans love falling in love, couples are often disillusioned to find that—after a brief neurochemical honeymoon period—their libidos go out of sync or they get bored or disgruntled with each other.

It may be that greater knowledge about the effects of sex on the brain could help mates keep the sparkle in their romances, or at least manage this challenge with more grace and compassion. Third, if orgasm, like fatty food, sometimes temporarily suppresses the brain's pleasure response and therefore promotes binging, this knowledge would be critical for today's porn viewers. In The Brain That Changes Itself , psychiatrist Norman Doidge records that some porn-using patients experience distressing to them escalation in extremeness of material viewed.

They also notice difficulty becoming aroused during sex with their partners. Should we find out whether superstimulating porn is exacerbating natural brain changes after orgasm, numbing responsiveness, increasing erectile dysfunction, and tampering with mood and perception?

For more see Brain Chemistry Research and Porn. Fourth, think of all the other questions we might address: Are there broad gender trends in the orgasm cycle? Would there be best points in the cycle for passionate sex? Best points for sticking to affectionate touch? How would a woman's menstrual cycle interact with an orgasm cycle? Which benefits of sex come from orgasm, and which from affectionate touch, or?

Are the brain effects of occasional masturbation the same as very frequent masturbation? Does extremeness of stimulation correlate with brain changes? Is there a law of diminishing returns at work in connection with intense stimuli? So what's stopping us from peeking into our brains for a week or two after orgasm—just in case something is going on that we should know about?

To track possible neurochemical changes after orgasm, researchers would need to ask some test subjects to orgasm. Others would have to refrain from orgasm for a couple of weeks—to serve as a control group. Yet Western researchers say they can't set up the necessary control groups because their ethics committees, which must pre-approve experiments, won't bless them. Despite a lack of evidence that avoiding orgasm for a couple of weeks is harmful to health, one researcher explained that he would hesitate to propose such an experiment because avoiding orgasm has been defined as a "paraphilia" by some experts.

Apparently there are people who get off on not getting off—for whom the thought of avoiding orgasm produces intense excitement and elevated dopamine levels. In any case, the screening process would weed out the rare person who avoids orgasm for kicks. A second researcher confirmed that test subjects avoiding orgasm to participate in an experiment or for any reason other than seeking jollies wouldn't be engaging in a paraphilia.

Yet he remained doubtful that Western ethics committees would approve an experiment calling for a week or two of abstinence. Yet, in this case the control subjects could bail out at will simply by climaxing.

It's worth noting that ethics committees have approved risky experiments such as surgically implanting a device in women's spines to see if they could be made to orgasm via remote control.

They have also approved asking subjects not to sleep for days, despite severe distress.